Fig. 2.
Effects on neuronal firing rate and epileptiform activities of suppression synaptic excitation and inhibition at 8.5 mm [K+]o.A, Glutamate receptor antagonists NBQX (10 μm) and d-APV (50 μm) abolish 8.5 mm [K+]o-induced interictal and ictal epileptiform activity in P15 (left traces) and interictal epileptiform discharges in P30 (right traces) rat hippocampal slices. GABAA-R antagonist bicuculline (10 μm) diminishes neuronal firing at P15 and increases the firing rate at P30. Extracellular recordings from CA3 pyramidal cell layer.B, The frequency of MUA (in sec−1) recorded from the CA3 pyramidal cell layer after the application of NBQX and d-APV and then after the application of bicuculline. C, Age dependence of the effect on MUA of suppression synaptic excitation and inhibition at 8.5 mm[K+]o.