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Endogenous κ-receptor agonist dynorphin inhibits glutamate EPSCs. A, EPSCs from a secondary cell in control, in dynorphin (300 nm), and after washout of dynorphin. B, A plot of normalized amplitudes of pooled EPSCs from secondary cells in control (open circles, n = 11) and in nor-BNI (100 nm, filled circles, n = 10). C, A dose-response plot of EPSC inhibition by dynorphin in secondary cells (n = 7-8 cells at each concentration).
