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Reduced levels of active Rac1, Cdc42, and increased active RhoA in Lis1+/- cerebellum. A-C, Pull-down assays reveal decreased GTP-bound Rac1 (A) and Cdc42 (B), whereas GTP-bound RhoA is increased in brain lysates of Lis1+/- animals. Total levels of Rac1, Cdc42, and RhoA proteins are unchanged. D, Activity of Rho GTPases expressed as percentage of control level is reduced in Lis1+/- cells (n = 3 experiments; 12 animals per genotype). *p < 0.01.
