Figure 4.
MPTP-induced microglial activation is attenuated within the SNc but not the striatum in Fas-deficient mice. Photomicrographs display immunoreactivity for the microglial marker cd11b within the SNc of wild-type mice that received saline (A) or MPTP (C) as well as Fas null animals treated with saline (B) or MPTP (D). Correspondingly, cd11b immunoreactivity within the striatum is displayed for wild-type mice administered saline (E) or MPTP (G) as well as Fas null animals receiving saline (F) or MPTP (H) injections. Quantitative analysis of the relative density of cd11b within the SNc (bottom left) and striatum (bottom right) confirmed that microglial recruitment-activation after MPTP was attenuated in Fas null mice only within the SNc. *p < 0.05 relative to Sal WT or Sal Fas. Error bars represent SEM.