Figure 3.
Fas-deficient mice are resistant to the death-inducing effects of MPTP on dopaminergic SNc neurons. The photomicrographs reveal that MPTP treatment provoked a loss of TH+ neurons within the SNc of wild-type mice (C) but not Fas-deficient mice (D) relative to saline-treated wild-type mice (Sal WT) (A) or saline-treated Fas null mice (Sal Fas) (B). Quantitative analyses across multiple levels of the SNc confirmed the MPTP-induced TH+ loss in wild-type mice (MPTP WT) but not Fas mice (MPTP Fas) (E). *p < 0.05 relative to Sal WT. Error bars represent SEM.