Figure 2.
NRG reduced the amplitude, but not the paired-pulse ratio, of NMDAR EPSCs in PFC slices. A, Plot of peak NMDAR EPSCs showing that NRG (4 nm) application reversibly reduced the amplitude of NMDAR-mediated synaptic responses. B, Representative current traces (average of 3 trials) taken from the records used to construct A (at time points denoted by #). Calibration: 50 pA, 0.1 s. C, Plot of peak NMDAR EPSCs evoked by double pulses (interstimuli interval, 100 ms) as a function of time and NRG application. D, Representative traces of NMDAR EPSCs (average of 3 trials) taken from the records used to construct C (at time points denoted by #). Calibration: 50 pA, 0.1 s. E, Cumulative data (mean ± SEM) showing the percentage of change of NMDAR EPSC amplitude and PPR by NRG. ctl, Control.