Fig 4. Model trajectory fits.
Subplots A-E correspond to groups A-E as described in Fig 1. Exposure events are as described in Table 1. Coloured lines show the posterior median latent antibody trajectories following exposure. Coloured shaded regions show 95% credible intervals of the model fit. Bars show 95% prediction intervals on observable titres. Coloured points show observed discrete log antibody titres by HI assay for each of the three individual ferrets in each group. Gray shaded regions show the upper and lower limits of detection in the assay. For the same ferrets, titres to A/H3N2 strains are shown in the left column and A/H1N1 strains in the right column. Red dashed lines show times of exposures. Symbols above each subplot: star represents infection; syringe represents TIV; and syringe with gray border represents TIV + adjuvant. Symbols are coloured based on their formulation. TIV 1 contained the following influenza A strains: A/Solomon Islands/3/2006 (H1N1) and A/Brisbane/10/2007 (H3N2). TIV 2 contained: A/Solomon Islands/3/2006 (H1N1) and A/Wisconsin/67/2005 (H3N2).