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. Author manuscript; available in PMC: 2019 Dec 24.
Published in final edited form as: Nat Struct Mol Biol. 2019 Jun 24;26(7):599–606. doi: 10.1038/s41594-019-0245-7

Figure 2 |. hENT1cryst structures capture the outward-facing state.

Figure 2 |

a, Dilazep and NBMPR bound human ENTcryst adopt outward-facing conformations. b, The extracellular thin gate cradles part of dilazep (top left), whereas NBMPR does not physically contact the thin gate (top right). The thick gate (bottom) tightly seals the central cavity from the intracellular side in both inhibitor bound structures. Hydrophobic residues highlighted in grey, with polar and charged residues shown as sticks.