Figure 2.
Increased TSPO expression in spinal cords of EAE-induced rats compared with those of controls. Spinal cord homogenates were prepared from EAE rats (n = 7) at maximum deficit (neurologic scores of 4–5) and controls (n = 6) and analyzed for their TSPO content by Western blot. Higher levels of TSPO are present in spinal cords of EAE-induced rats versus those of controls (A). First lane on the left, an adrenal gland extract, used as positive control for TSPO expression. TSPO levels (normalized to those of α-tubulin) are approximately fivefold higher in spinal cords of EAE rats (B). ***p = 0.0001.