Extended Data Fig. 6. Gene-based association of extremely rare variants in ALDH1L1 with glycine levels.
The upper panel shows the distribution of the covariate adjusted and inverse-normal transformed phenotype. The lower panel displays the association statistics for each variant included in the gene-based test, along with the trait value for minor allele carriers of each variant (orange triangles). SV.P is the P-value from the analysis of each variant in a single-variant analysis. The number of independent individuals in the analysis is 8,206.