Figure 3. Geographical clustering of associated variants.
A) Example of geographical clustering for a novel trait-associated variant (Table 1). The map shows birth locations of all 113 parents of carriers (orange) and 113 randomly selected parents of non-carriers (blue) of the minor allele for rs780671030 in ALDH1L1.
B) FDH mutations (N=38) geographically cluster (by parental birthplace) similarly to trait-associated variants (Table 1) that are >10x more frequent in FMS than in NFE (N=12) and more than enriched variants from our combined analysis (N=7). For all variants, carriers clustered more than non-carriers (center line, median; box limits, upper and lower quartiles; whiskers, 1.5 interquartile range; points, outliers).