Figure 2.
Characteristics of TTX-resistant sodium currents in mouse DRG neurons. A, Representative current response showing a prominent A-type K+ current used to identify TTX-R expressing DRG neurons. IA was evoked using the voltage protocol shown above the current trace. B, Representative inward Na+ current recorded before and after application of TTX (250 nm for 3 min). Note that traces of predrug and with TTX are superimposed. TTX had no effect on Na+ currents in IA-positive DRG neurons. C, Representative current–voltage relationship for peak TTX-R currents. D, Steady-state inactivation (n = 12) and activation (n = 15) curves for TTX-R currents obtained using the voltage protocols shown above the graphs.