Figure 7.
Chronic nicotine treatment reduces the threshold for LTD induction in unlesioned and MPTP-lesioned monkeys. The threshold of LTD induction was defined as the minimal number of HFS pulses required to generate a significant long-term (>20 min) decrease in EFP amplitude compared with baseline. Shown are the combined results from three to four monkeys per group, with each bar representing the mean ± SEM of amplitude of EFPs after HFS (expressed as a percentage of baseline). Significance of difference from baseline was determined using one-way ANOVA followed by a Newman–Keuls post hoc multiple comparison test (*p < 0.05).