Figure 6.
Magnitude of NMDA receptor-mediated LTP at the Schaffer collateral to CA1 pyramidal neuron synapse induced by theta burst stimulation is normal in ephrin-B3 mutant mice. ai–aiii, Time course of CA1 LTP in ephrin-B3 mutant and wild-type mice. Control wild-type littermate recordings from both groups showed no significant difference in the magnitude of LTP and were therefore grouped together. b, Representative CA1 fEPSPs before and after the induction of LTP for ephrin-B3wt/wt, ephrin-B3lacZ/lacZ, and ephrin-B3neo/neo mice. Calibration: 20 ms, 0.4 mV. c, Cumulative distribution histogram of CA1 LTP from ephrin-B3 mutants.