Figure 7.
On-cell peak firing rate as a function of the von Frey filament force. Activity recorded during stimulation of the ligated side in nerve-injured animals compared with nonligated side and to activity recorded in sham-operated and normal, unoperated controls. With stimulation of the ligated side, peak firing rate increased in a graded manner with stimulus force through the innocuous range (within-subject ANOVA showed a significant linear trend, p < 0.0001). At noxious intensities, peak firing rate was equivalent across groups and similar to activity associated with noxious thermal stimulation (8–11 cells per group; data expressed as mean ± SEM).