Table 1.
Significant changes (increase of cerebral gray matter) during the time of skilled performance (scan 2) compared with time point one
| Region | Brodmann's areas | Talairach coordinates (x, y, z) | Z score of peak activation |
|---|---|---|---|
| Main effects analysis (n = 25) | |||
| R hMT/V5 | 18 | 25, −92, −1 | 4.03* |
| L Hippocampus | −18, −11, −21 | 4.79 | |
| Cingulate cortex | 24 | −3, 40, 6 | 4.07 |
| L Superior frontal gyrus | 10 | −17, 61, −3 | 3.54 |
| R Gyrus precentralis | 4 | 12, −21, 74 | 4.72 |
| Interaction analysis (n = 50) | |||
| hMT/V5 R | 18 | 24, −91, 3 | 3.21 |
| L Hippocampus | −18, −11, −21 | 4.45 | |
| L Nucleus accumbens | −19, 3, −14 | 4.79 | |
| R Nucleus accumbens | 19, 5, −13 | 4.01 |
This pattern reversed when study participants were examined at time point 3 (after the weeks without practicing). The changes are tabulated in terms of the brain region and the corresponding Brodmann's area. The x, y, and z coordinates are according to the Montreal Neurological Institute and International Consortium for Brain Mapping (http://www.loni.ucla.edu/ICBM/). Each location is the peak within a cluster (defined as the voxel with the highest Z-score). L, Left; r, right.
*Corrected for multiple comparisons (SVC).