Table 2.
Summary of observed pathologies in CNS of 5-month-old Nes-Pex5 knock-out mice
| Lipid accumulation | Astrogliosis | Microgliosis | Myelin defect | Axonal damage | Cell death | Catalase upregulation | |
|---|---|---|---|---|---|---|---|
| Optic nerve | − | − | − | − | − | − | − |
| Cortex | x | xx (V) | xx (V) | x | xx (V) | − | x |
| Cc | x | xx | xxx | xxx | xxx | x | xxx |
| Fornix | x | xx | xxx (V) | xxx (V) | xx (V) | − | xx |
| Anterior commissure | x | xx | xx | x (V) | − | − | xx |
| Hippocampus | x | xx | xx | − | xx | − | x |
| Thalamus | x | xx | xx | − | xx | − | xx |
| Hypothalamus | x | xx | xx | − | xx | − | xx |
| Sup coll | x | xx | xx | − | xx | − | xx |
| Inf coll | x | xx | xx | − | xx | − | xx |
| Midbrain | x | xx | xx | − | xx | − | xx |
| Pons | x | xx | xx | − | xx | − | xx |
| Medulla | x | xx | xx | − | xx | − | xx |
| Cerebellum | |||||||
| ML | xxx | x | x | − | xx | − | xx |
| GL | x | x | x | − | xx | − | xx |
| Whm | x | x | x | xx | xxx | − | xxx |
| Spinal cord | x | xx | xx | x (V) | x (V) | − | / |
−, Not present; x, present; xx, more present; xxx, most present; V, variable between mice; /, not investigated. Abbreviations: Cc, corpus callosum; sup coll, superior colliculus; inf coll, inferior colliculus; ML, molecular layer; GL, granular layer; Whm, white matter.