. 2009 Sep 23;29(38):11772–11782. doi: 10.1523/JNEUROSCI.1242-09.2009

Table 5.

Regression analyses with cortical lobe volumes, thickness, and surface area

	Regression with age				Regression with age and age²
	β	F	p	R²	F	p	R²	p age^2a
Volume
Total cortex	−0.83	384.98	1.98E-45	0.36	276.27	7.64E-54	0.38	1.94E-11
Frontal	−0.58	85.14	1.12E-16	0.34	43.42	6.29E-16	0.34	0.227
Parietal	−0.67	135.72	2.12E-23	0.45	87.36	9.81E-27	0.51	5.43E-06
Temporal	−0.41	34.86	1.89E-08	0.17	17.69	1.07E-07	0.17	0.442
Occipital	−49	54.47	6.83E-12	0.24	32.34	1.31E-12	0.28	0.005
TBV-corrected volume
Total cortex	−0.83	384.98	1.98E-45	0.70	276.27	7.64E-54	0.77	1.94E-11
Frontal	−0.77	238.48	4.02E-34	0.59	130.30	6.80E-35	0.61	0.002
Parietal	−0.79	281.04	8.81E-38	0.62	253.31	1.93E-51	0.75	1.09E-16
Temporal	−0.61	98.02	1.64E-18	0.37	53.37	1.14E-18	0.39	0.016
Occipital	−0.55	72.65	8.31E-15	0.30	48.41	2.51E-17	0.37	5.33E-05
Thickness
Total cortex	−0.81	314.81	1.91E-40	0.65	181.89	9.22E-43a	0.68	4.09E-5
Frontal	−0.76	233.44	1.16E-33	0.58	129.26	1.03E-34	0.61	0.001
Parietal	−0.82	345.42	2.42E-43	0.68	225.70	2.52E-48	0.73	6.54E-8
Temporal	−0.53	66.10	8.74E-14	0.28	33.62	5.24E-13	0.29	0.297
Occipital	−0.77	239.56	3.21E-34	0.59	157.29	3.21E-39	0.65	7.68E-8
Surface area
Total cortex	−0.32	18.80	2.49E-5	0.10	10.23	6.42E-5	0.11	0.208
Frontal	−0.33	21.18	8.18E-6	0.11	10.76	4.02E-5	0.11	0.525
Parietal	−0.35	24.27	1.98E-6	0.13	16.40	3.12E-7	0.16	0.007
Temporal	−0.22	8.34	0.004	0.05	4.20	0.017	0.05	0.759
Occipital	−0.18	5.73	0.018	0.03	3.64	0.028	0.04	0.218

Results shown are from two separate regression analyses with both raw and TBV-corrected lobar volumes, thickness, and surface area, one with only age as the predictor variable and the other with both age and age² as predictor variables. Bold characters for R² indicate a statistically significant quadratic age relationship.

^aThe p value for the unique contribution of age² to the explained variance in brain volume.