Table 1.
Body weight, spleen weight, and cellularity of spleen, MLNs, and BM of 16‐wk‐old WT and Ercc1−/Δ7 mice, with or without dietary TrpR
| Parameters | WT control | WT TrpR | Ercc1−/Δ7 control | Ercc1−/Δ7 TrpR |
|---|---|---|---|---|
| Body weight (g) | 24.0 ± 0.64 | 15.4 ± 0.70*** | 14.2 ± 0.43 | 7.3 ± 0.28*** |
| Spleen weight (mg) | 50 ± 4.0 | 25 ± 1.5** | 24 ± 1.3 | 11 ± 0.71*** |
| Relative spleen weight (%) | 0.21 ± 0.012 | 0.16 ± 0.012# | 0.17 ± 0.0047 | 0.15 ± 0.0062# |
| Spleen (No. ×106) | 115 ± 27 | 35 ± 7.8# | 42 ± 9.5 | 15 ± 1.6# |
| MLN (No. ×106) | 6.5 ± 2.0 | 5 ± 2.3 | 4.2 ± 0.53 | 1.1 ± 0.11* |
| BM (No. ×106) | 81 ± 6.7 | 97 ± 15 | 45 ± 5.6 | 40 ± 2.3 |
Two femurs were counted for the BM count. Data represent the means ± sem of n = 3–4 mice per group. Significant differences between control and TrpR are depicted with asterisks. # P < 0.1; *P < 0.05; **P < 0.01; ***P < 0.001.