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Pharmacological properties of G1, G2, and G3 Ca2+ channels
| G1 | G2 | G3 | |
|---|---|---|---|
| Nimodipine (3 μm) | no | no | no |
| ω-CgTx-GVIA (2 μm) | no2_a | no2_a | no2_a |
| ω-CTx-MVIIC (3 μm) | yes | no2_a | no2_a |
| ω-AgaIVA (50 nm) | yes | no | no |
Refers to irreversible block; our data do not exclude that some G channels might be reversibly and partially blocked by ω-CgTx-GVIA and/or ω-CTx-MVIIC.
The concentrations of toxins and nimodipine indicated in parentheses are saturating for block.
