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Firing rate histogram of mechanosensitive non-nociceptive neuron before and after administration (open triangle) of WIN 55,212-2 (0.25 mg/kg, i.v.). The cannabinoid agonist did not significantly reduce the responses of mechanosensitive neurons to tap stimuli (filled triangles) administered every minute. Note the reduction in spontaneous activity after the drug and the more robust response to the stimulus in this cell after the drug.
