Fig. 2.
LTD in the CA1 region in vivo is modulated by group 1 mGluRs. A, The group 1 mGluR antagonist 4CPG (20 mm/5 μl; n = 7) partially impairs LTD when compared with vehicle-injected controls (n = 12), from t = 120 min post-LFT. This effect was significantly different from baseline values.B, Original analog traces showing evoked responses in the CA1 region at three time points: preinjection,t = 5 min, and t = 4 hr post-LFT, in an animal injected with 4CPG (20 mm/5 μl).C, Dose–response curve for the antagonist effect of 4CPG (2–40 mm/5 μl) on LTD in the CA1 region. The values represent the magnitude of LTD observed at 4 hr post-LFT.D, Application of 4CPG (20 mm/5 μl;n = 5) 5 min after LFT results in a significant inhibition of LTD, from t = 135 min post-HFT compared with vehicle-injected controls (n = 5). *p < 0.05. Line breaks(//) indicate change in time scale.