Fig. 5.
Neuronal expression of the p75NTR-ICD leads to the loss of neurons within the neocortex. Shown are photomicrographs of Nissl-stained coronal sections of the neocortex of control and transgenic p75NTR-ICD animals. Right andfar left photographic panels are from control animals, whereas the three inner panels are all from transgenic animals of the 4173 line. The area examined is indicated in the schematic drawings shown at left, with the top panels representing the rostral level of the neocortex and the bottom panels representing the caudal level. Each vertically aligned pair of photomicrographs is derived from the same animal. Brackets in the far left panel indicate approximate boundaries of the different cortical layers. Scale bar, 75 μm. Neuronal counts reveal a highly significant loss of cortical neurons in the p75NTR-ICD (p < 0.001; see Results).