Fig. 3.
Effect of intravenous administration of a D1 agonist on the discharge activity of selected striatal neurons. Fourteen single striatal neurons were selected for their obvious delayed excitatory response to MFB stimulation (see Fig. 2). Their discharge activity was recorded for 7 min, and the D1 agonist SKF 82958 was administered (50 μg/kg, i.v.) after a control period lasting for 200 sec. The figure shows a representative recording. In 13 neurons, this drug treatment increased the number of spike discharges recorded during the 200 sec after administration from +89% to +4483% (mean +1142%) compared with that recorded during the control period. One neuron was not affected.