Fig. 1.
Regulation of BDNF mRNA in hippocampus and neocortex by DOI. The influence of an acute injection of vehicle or DOI (8 mg/kg) on levels of BDNF mRNA was determined by in situ hybridization as described in Materials and Methods. Representative autoradiographs from the vehicle- and DOI-treated groups are shown. Levels of BDNF mRNA in the CA1, CA3, dentate gyrus (DG), parietal cortex (Par Ctx) and piriform cortex (Pir Ctx) were determined by quantitative densitometry. Results are expressed as percent of vehicle and are the mean ± SEM (n = 6). *p < 0.05 compared with vehicle (Student’st test).