Table 1.
Neuronal numbers at different embryonic stages in wild-type and mutant mice
| E11 | E12 | E13 | E14 | P0 | |
|---|---|---|---|---|---|
| w/t | 1486 ± 74 | 3048 ± 110 | 5267 ± 78 | 3977 ± 142 | 4033 ± 56 |
| (n = 6) | (n = 11) | (n = 4) | (n = 10) | (n = 16) | |
| bdnf−/− | 1373 ± 38 | 2702 ± 96 | n.d. | 3032 ± 63 | 1661 ± 81c |
| (n = 4) | (n = 4) | (n = 4) | (n = 8) | ||
| nt3−/− | 1591 ± 102 | 2432 ± 127a | n.d. | 2385 ± 63b | 2361 ± 65c |
| (n = 6) | (n = 6) | (n = 5) | (n = 6) | ||
| nt4−/− | 1339 ± 56 | 2733 ± 80 | 2526 ± 163b | 1863 ± 99c | 1724 ± 33c |
| (n = 10) | (n = 9) | (n = 6) | (n = 12) | (n = 8) |
Number of neurons in the N/P ganglion of mice fromw/t, bdnf−/−,nt3−/−, and nt4−/−genotypes at indicated developmental stages (± SEM). n= number of ganglia counted at each indicated time point. Student’s t test.a p < 0.05;b p < 0.01;c p < 0.001. n.d., Not determined.