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Two-compartment model of whole-organism branched chain amino acid (BCAA) physiology. BCAAs appear in circulation when released from protein, from either the diet or tissues. BCAAs can leave the circulation to be deposited into new protein. All BCAAs are ultimately cleared from the system when oxidized in tissues. Many factors promote or inhibit each of these processes (grey arrows). The tissue-specific regulation of protein turnover and oxidation is poorly understood.
