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. 2019 May 14;9:7377. doi: 10.1038/s41598-019-43625-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PDMS with PDMS-PEG BCP additives exhibit lower protein adsorption. Adsorption of fluorescently labeled albumin and lysozyme onto BCP modified PDMS slabs (a) without any treatment (b) after IPA soak and 1 week after O₂ plasma. Samples were covered with protein solutions for 30–90 minutes. PDMS with PDMS-PEG BCP additive showed high adsorption, whereas PDMS modified with 1% w/w PDMS-PEG block copolymer exhibited significantly lower adsorption, near detection limit (n = 5). Image scale bar: 400 μm. (c) We measured adsorption of IgG, BSA, and lysozyme in modified microfluidic devices, comparing the influx and efflux concentrations after IPA soaking and a week after O₂ plasma. PDMS-PEG BCP additive leads to significantly reduced adsorption for all proteins. Error bars represent the standard deviation with samples measured in triplicate (n = 3).