Figure 6.
Overexpression of LINC-ROR Attenuated Sorafenib Sensitivity In Vivo
(A) HepG2-lv-vector or HepG2-lv-LINC-ROR cells were implanted into nude mice. When the average tumor volume reached 50 mm3, the two groups of mice were subdivided into four groups randomly and were given 60 mg/kg sorafenib or PBS. Tumor sizes were calculated every 5 days. Images of subcutaneous xenograft tumors were taken. (B) Growth curves of the subcutaneous xenograft tumors were calculated; the bars indicate the SD. (C) The final tumor weights were measured and calculated. (D) Representative images of H&E staining, immunohistochemical staining (for FOXM1, Ki-67 and PCNA), and TUNEL staining are shown. H&E staining and TUNEL staining: scale bar, 50 μm; immunohistochemical staining for FOXM1, Ki-67, and PCNA: scale bar, 100 μm (*p < 0.05, **p < 0.01, ***p < 0.001; ns, not significant).