. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: J Autoimmun. 2019 Mar 14;99:15–23. doi: 10.1016/j.jaut.2019.01.006

Table 2.

Association of Combination 1 antibodies with exposure variables

A1. Reduced models without interactions: all participants^*
	Male (N=113)		Female (N=147)		All (N=260)

Parameter	estimate	p-value	estimate	p-value	estimate	p-value
age	0.083	0.0000031			0.042	0.00000064
E (legacy mine exp)	0.38	0.010			0.14	0.038
M (mine work)					−0.33	0.032
Navajo use			0.27	0.027
A2. Reduced models with second order interactions (involving age and E•P): all participants^*
Parameter	Male (N=113)		Female (N=147)		All (N=260)

	estimate	p-value	estimate	p-value	estimate	p-value

age	0.17	0.000056	0.053	0.023	0.031	0.0025
E (legacy mine exp)			0.47	0.044
P (proximity)			66	0.010	13.9	0.0065
M (mine work)	−5.5	0.028			−0.45	0.0058
E:P			−9.5	−0.014	−5.5	0.0053
Navajo use	−0.85	0.013
age:M	0.073	0.029
age:E	−0.031	0.0058
U consumption			0.24	0.033
B1. Reduced models without interactions: biomonitored participants^*
	Male (N=89)		Female (N=104)		Both (N=193)

Parameter	estimate	p-value	estimate	p-value	estimate	p-value

age	0.24	0.00017			0.043	0.00016
E (legacy mine exp)	0.66	0.000099			0.21	0.0052
M (mine work)	−0.73	0.033
Navajo use	−1.2	0.010
As consumption	0.89	0.031
Hg consumption			−1.1	0.029
urinary U					0.69	0.049
B2. Reduced models with second order interactions (involving age and E•P): biomonitored participants^*
	Male (N=89)		Female (N=104)		Both (N=193)

Parameter	estimate	p-value	estimate	p-value	estimate	p-value

age			0.28	0.0038	0.27	0.00045
E (legacy mine exp)			0.55	0.049
P (proximity)			22	0.042	119	0.031
Ni consumption			3.1	0.0091	3.3	0.0036
age:P					−2.0	0.033
age:urinary Ni			−0.055	0.0039	−0.05	0.0018
age:urinary U					0.088	0.013
As consumption			0.74	0.027
Hg consumption			−1.3	0.0048

Only results of statistical analysis with p-values <0.05 are included.