Table 1.
Metabolites with Significant Changes in Their Abundance among the Four Liver Sample Groups
| name | CAS | 1tR (s) | 2tR (s) | FC-1a | FC-2b | FC-3c | p-1d | p-2e | p-3f |
|---|---|---|---|---|---|---|---|---|---|
| Fatty Acids | |||||||||
| acetic acidg | 67226-76-0 | 1443 | 1.01 | −1.05 | 2.05 | 1.22 | 1.3 × 10–3 | 9.0 × 10−1 | 2.9 × 10–1 |
| dodecanoic acid | 143-07-7 | 1961 | 1.04 | −1.41 | 1.59 | −1.09 | 8.9 × 10–3 | 7.6 × 10–2 | 4.7 × 10–1 |
| hexanoic acid | 142-62-1 | 1113 | 1.00 | −1.23 | 1.56 | −1.09 | 2.1 × 10–3 | 2.4 × 10–1 | 8.1 × 10–1 |
| tetradecanoic acid | 4544-63-8 | 2196 | 1.06 | −1.62 | 1.42 | 1.20 | 9.0 × 10–1 | 4.4 × 10–1 | 4.4 × 10–2 |
| cis-9-hexadecenoic acidg | 373-49-9 | 2385 | 1.11 | −1.40 | 2.25 | 1.26 | 8.2 × 10–3 | 9.9 × 10–1 | 1.0 × 10–1 |
| trans-9-octadecenoic acidg | 112-79-8 | 2594 | 1.17 | −2.44 | −1.28 | −2.28 | 3.6 × 10–1 | 3.1 × 10–2 | 8.5 × 10–1 |
| mead acidg | 20590-32-3 | 2793 | 1.51 | 1.01 | 1.82 | 1.59 | 3.5 × 10–2 | 2.7 × 10–1 | 1.7 × 10–1 |
| arachidonic acidg | 506-32-1 | 2762 | 1.51 | 1.35 | −1.55 | 1.10 | 1.7 × 10–2 | 7.9 × 10–2 | 4.0 × 10–1 |
| Amino Acids | |||||||||
| L-isoleucine | 73-32-5 | 1748 | 0.99 | 1.43 | −1.09 | 1.20 | 1.0 × 1000 | 3.9 × 10–3 | 2.8 × 10–1 |
| L-proline | 147-85-3 | 1803 | 1.08 | 1.33 | −1.46 | 1.13 | 1.7 × 10–3 | 2.2 × 10–2 | 2.5 × 10–1 |
| L-threonine | 72-19-5 | 1769 | 1.05 | 1.20 | −1.08 | −1.18 | 7.1 × 10–5 | 1.4 × 10–1 | 1.3 × 10–2 |
| L-phenylalanine | 63-91-2 | 2189 | 1.16 | 1.28 | −1.10 | 1.31 | 3.2 × 10–1 | 2.8 × 10–2 | 9.9 × 10–1 |
| L-tyrosine | 60-18-4 | 2768 | 1.38 | 1.22 | 1.02 | 1.20 | 6.6 × 10–1 | 1.6 × 10–2 | 8.8 × 10–1 |
| L-valine | 72-18-4 | 1652 | 0.99 | 1.34 | −1.06 | 1.16 | 9.7 × 10–1 | 3.0 × 10–2 | 4.8 × 10–1 |
| Other Acids | |||||||||
| 2-aminobutanoic acid | 2835-81-6 | 1585 | 0.99 | −2.16 | 3.57 | −1.14 | 2.5 × 10–4 | 1.3 × 10–1 | 8.0 × 10–2 |
| glycolic acidg | 79-14-1 | 1443 | 1.01 | −1.05 | 2.05 | 1.22 | 1.4 × 10–3 | 9.0 × 10–1 | 2.9 × 10–1 |
| α-ethylphenylacetic acidg | 90-27-7 | 2499 | 1.29 | 1.30 | −2.39 | 1.04 | 9.6 × 10–4 | 3.7 × 10–1 | 7.2 × 10–1 |
| Others | |||||||||
| 3-pyridinolg | 109-00-2 | 1245 | 1.20 | −1.18 | 1.43 | 1.46 | 3.3 × 10–1 | 2.8 × 10–1 | 1.2 × 10–2 |
| hypoxanthineg | 68-94-0 | 2345 | 1.43 | −1.09 | 1.55 | 1.26 | 3.2 × 10–3 | 5.1 × 10–1 | 9.4 × 10–2 |
| 2-(2-(2-ethoxyethoxy)ethoxy)acetic acidg | 16024-58-1 | 2456 | 1.05 | 4.20 | −4.04 | 1.14 | 4.3 × 10–3 | 3.9 × 10–3 | 1.5 × 10–2 |
a
Fold change for AF-1 to AF-0.
b
Fold change for AF-0 to PF-0
c
Fold change for PF-1 to PF-0.
d
p-value of factor alcohol.
e
p-value of factor LGGs.
f
p-value of the interaction of alcohol and LGGs.
g
Tentative identification without using authentic standards.