Figure 6.
Parameter distributions strongly influence model dynamics. The standard deviation of the parameter distributions were varied from 0.01 to 2.56·μ. Sampled parameters are: Vmax of transcription (tc), translation rates (tl), and the degradation rate of NICD (nicd_deg) or all of the above. Initial values for new agents were sampled accordingly under all scenarios. Model output for 20 simulations of each setting have been recorded as (A), the maximal number of active tip cells (B), and the time of the first tip cell (C). If no tip cells occur during a simulation run (199 h), we set the time to the first tip cell to 1,000 h. Plotted values are given in Table S2.