Figure 7.
Propionate reduces susceptibility to ventricular arrhythmias in AngII-infused wild-type NMRI (WT) mice. In vivo programmed electric ventricular stimulations were performed in AngII-infused WT mice treated with C3 or control. A, Representative original tracings showing the induction of ventricular tachyarrhythmia. Surface ECG, right ventricular (RV), and right atrial (RA) recordings are shown. B, Quantification of ventricular arrhythmias susceptibility. n=7 per group, *P<0.05 by Mann-Whitney test. C, Immunofluorescent costaining of connexin 43 (green) and N-cadherin (red) in cardiac cryosections from sham-infused or AngII-infused WT mice treated with C3 or control. WT Sham n=7, WT AngII n=5, WT AngII+C3 n=7. Representative photomicrographs (scale bar=100 µm) and quantification of colocalization. P values by 1-way ANOVA and Tukey post hoc. AngII indicates angiotensin II; and C3, propionate.