FIG 8.
Mutations affecting neutralization by group 7 sera (BG505 SOSIP.v4.1 + N241-KI + N332-KO trimer immunogen). The layout in panel A is analogous to that of Fig. 5A. To illustrate the hole created by the N332-KO mutation, the glycan knocked in at residue 241 is colored yellow on both images and the glycan knocked-out at residue 332 (left) and residue 332 itself (right image) are both colored red. The layout of panel B is comparable to that of Fig. 2B, where the color code is explained. Four cells are open for r2243-7 because the ID50 value against the parental virus was <100 and, hence, was too low for precise mapping.