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Mutations affecting neutralization by group 5 sera (BG505 SOSIP.v4.1 + N241-KI + N234-KO trimer immunogen). The layout in panel A is analogous to that of Fig. 5A. The glycan knocked in at residue 241 is colored yellow on both images, and the glycan knocked out at residue 234 (left) and residue 234 itself (right) are both colored red to illustrate the hole created by the N234-KO mutation. The layout of panel B is analogous to that of Fig. 2B, where the color code is explained.
