. 2019 Jan 18;10:333. doi: 10.1038/s41467-018-08219-1

Table. 1.

Relationship between PS and birth location within UK Biobank

		P value for association between PS and geographical term
	Axis	Model 1	Model 2	Model 3	Model 4	Model 1	Model 2	Model 3	Model 4
P (5.0e−08)		BMI (GIANT)
	N/S	9.7e−7	9.9e−7	0.063	0.40	0.0013	0.0012	0.0032	0.58
	E/W	0.0036	0.0035	0.24	0.93	0.053	0.054	0.032	0.47
		EA (SSGAC)
	N/S	2e−16	<2e−16	6.4e−6	6.7e−6	<2e−16	<2e−16	1.3e−9	1.6e-6
	E/W	<2e−16	<2e−16	1.5e−9	6.0e−11	<2e−16	<2e−16	7.5e−14	1.3e-11
		Height (GIANT)
	N/S	<2e−16	<2e−16	1.3e−5	0.14	<2e−16	<2e−16	4.6e−06	0.13
	E/W	<2e−16	<2e−16	2.1e−4	0.095	<2e−16	<2e−16	3.4e−05	0.046
P (1.0e−05)		BMI (GIANT)
	N/S	2.4e−9	2.5e−09	0.023	0.019	2.4e−10	2.6e−10	0.0029	0.074
	E/W	1.4e−13	1.7e−13	0.134	0.34	<2e−16	<2e−16	0.020	0.14
		EA (SSGAC)
	N/S	<2e−16	<2e−16	<2e−16	<2e−16	7.6e−11	8.5e−11	0.012	0.16
	E/W	<2e−16	<2e−16	<2e−16	<2e−16	9.7e−12	8.9e−12	0.0021	0.041
		Height (GIANT)
	N/S	<2e−16	<2e−16	5.9e−5	0.16	<2e−16	<2e−16	2.5e−4	0.17
	E/W	<2e−16	<2e−16	1.4e−4	0.051	<2e−16	<2e−16	7.2e−5	0.014
		Weighted PS				Unweighted PS

P value for non-linear association between component of birth location and polygenic score. For all models n = 321,439. Statistical adjustment was performed as follows: model 1: no adjustment; model 2: adjustment for genotyping array only; model 3: adjustment for genotyping array, 10 PCs and study participation centre; model 4: adjustment for genotyping array, 40 PCs and study participation centre

N/S north/south axis of birth location, E/W east/west axis of birth location, PS polygenic scores, BMI body mass index, GIANT Genetic Investigation of ANthropometric Traits, EA educational attainment, SSGAC Social Science Genetic Association Consortium