Figure 4.
Gene expression characteristics of the 3 synovial subtypes. A, Enrichment scores of functional annotation clusters of genes with increased expression in the high inflammatory subtype compared to the other subtypes. B, Enrichment scores of functional annotation clusters of genes with increased expression in the low inflammatory subtype compared to the other subtypes. C, CIBERSORT-inferred fraction of leukocyte cell types according to the 3 synovial subtypes. * = P < 0.05, by Kruskal-Wallis test. MHCI/II = major histocompatibility complex class I/class II; ITIM = immunoreceptor tyrosine–based inhibition motif; TNF = tumor necrosis factor; CTL = cytotoxic T lymphocyte; GPI = glycoprotein I; NK = natural killer.