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. 2018 Dec 10;9:3062. doi: 10.3389/fmicb.2018.03062

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Copyright © 2018 Zhang, Hua, Zhang, Zhang, Yang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serine increased content of immunoglobulin and decreased content of inflammatory cytokines and colonic infiltration markers. (A–C) IgA, IgG, and IgM concentration in sera. (D–F) IL-1β, IL-6, and TNF-α concentration in colonic tissue. (G,H) MPO and EPO concentration in colonic tissue. Control, mice was rectally administrated with PBS without pretreatment with dextran sulfate sodium; DSS, mice was rectally administrated with PBS after pretreatment with dextran sulfate sodium; Ser, mice was rectally administrated with serine after pretreatment with dextran sulfate sodium. MPO, myeloperoxidase; EPO, eosinophil peroxidase. Values are expressed as mean ± SEM, n = 7. ^a,bMeans of the bars with different letters were significantly different among groups (P < 0.05).