TABLE 2.
Purine metabolites in infants fed SF, HM, or MF1
| Metabolite | Multiplier2 | SF | HM | MF |
|---|---|---|---|---|
| Adenosine | 1000,000 | 242 ± 129b | 135 ± 71 | 167.3 ± 78.2 |
| ADP | 1000 | 34 ± 27b | 7 ± 5 | 10.6 ± 6.6 |
| AICAR | 10,000 | 92 ± 293 | 3 ± 2 | 10.2 ± 10.0 |
| Allantoin | 100,000 | 13 ± 14 | 9 ± 10 | 7.7 ± 6.3 |
| AMP | 100,000 | 21 ± 39b | 1 ± 1 | 1.6 ± 1.5 |
| ATP | 100,000 | 12 ± 26 | 0.1 ± 0.1 | 0.0 ± 0.0 |
| cAMP | 100,000 | 88 ± 79b | 35 ± 25 | 51 ± 33 |
| GDP | 1000 | 57 ± 52b | 32 ± 22 | 31 ± 26 |
| GMP | 1000 | 60 ± 52b | 10 ± 9 | 22 ± 26 |
| GTP | 1000 | 69 ± 51b | 9 ± 9 | 34 ± 33 |
| Guanine | 1000,000 | 68 ± 38b | 35 ± 20 | 45 ± 21 |
| Guanosine | 10,000 | 29 ± 22b | 14 ± 8 | 20 ± 9 |
| Hypoxanthine | 1000,000 | 84 ± 73a | 75 ± 51 | 91 ± 47 |
| IMP | 10,000 | 21 ± 25b | 3 ± 3 | 6 ± 6 |
| Inosine | 1000,000 | 14 ± 9b | 12 ± 7 | 14 ± 10 |
| PRPP | 100,000 | 32 ± 21b | 14 ± 10 | 28 ± 16 |
| Uric acid | 1000,000 | 166 ± 179b | 40 ± 35 | 63 ± 52 |
| Xanthine | 1000,000 | 83 ± 50a | 77 ± 48 | 81 ± 67 |
| Xanthosine | 1000,000 | 17 ± 23b | 5 ± 3 | 7 ± 8 |
| XMP | 100 | 77 ± 79a | 12 ± 13 | 31 ± 19 |
1Values are mean ± SD peak intensity (n = 13 for SF, 14 for HM, and 13 for MF) normalized by the total number of peaks and per millimole of creatinine.
a P < 0.05 vs. HM group.
b P < 0.05 vs. HM and MF groups. AICAR, 5-aminoimidazole-4-carboxamide ribonucleotide; HM, human milk; IMP, inosine monophosphate; MF, milk formula; PRPP, 5-phospho-α-d-ribosyl 1-pyrophosphate; SF, soy formula; XMP, xanthosine monophosphate.
2Multiplication factor to be used to calculate the peak counts.