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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Cancer Res. 2018 Sep 25;78(22):6473–6485. doi: 10.1158/0008-5472.CAN-18-1642

Figure 4: Semaphorin 7a promotes macrophage-mediated lymphatic mimicry.

Figure 4:

A) SEMA7A is expressed on EpCAM+ cells at involution day 6. In mammary glands from SEMA7A−/− mice we observe decreased B) LECs, C) PDPN+ immune cells, D) monocytes, and E&F) monocytes and macrophages expressing PDPN. G) LYVE-1 (green) and F4/80 (brown) IHC on involution day 6 mouse mammary glands from WT (top) and SEMA7A−/− (KO—bottom). Inset, a-c and e-g are mammary gland and d and h are lymph node. Unpaired t-test: *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Scale bars=50μm.