Figure 6.
R7BP, but not GPR158, regulates the kinetics of GABAB-mediated GIRKs in primary hippocampal neurons. A, Representative normalized traces of GIRKs evoked by baclofen 100 μm from WT (GPR158+/+), GPR158 KO, and R7BP KO (left); R7BP KO and DKO (right). B, Deactivation time constant in GPR158KO, R7BP KO, DKO, and WT (*p < 0.05 R7BP KO vs WT, **p < 0.01 DKO vs WT, one-way ANOVA with Bonferroni's post tests). C–E, Amplitudes (C), activation (D), and desensitization (E) rates in GPR158KO, R7BP KO, DKO, and WT (p > 0.05, n = 10–15).