Table 1.
Inhibitory Potency of the Designed Analogues on the Production of IL-1β by J774A.1 Cells upon Stimulation with LPS/ATP
 |
||||
|---|---|---|---|---|
| Compound | R1 | R2 | n= | IC50(μM) |
| JC124 |  |
 |
1 | 3.25 ± 1.34 |
| 1. |  |
 |
1 | 13.36 ± 2.26 |
| 2. |  |
 |
1 | 17.10.25 ± 4.32 |
| 3. |  |
 |
1 | 146.56 ± 26.31 |
| 4. |  |
 |
1 | 10.48 ± 0.091 |
| 5. |  |
 |
1 | 31.78 ± 3.19 |
| 6. |  |
 |
1 | 18.031 ± 0.27 |
| 7. |  |
 |
1 | 44.42 ± 6.32 |
| 8. |  |
 |
1 | 5.83 ± 1.36 |
| 9. |  |
 |
1 | 32.75 ± 3.78 |
| 10. |  |
 |
1 | 2.01 ± 0.43 |
| 11. |  |
 |
1 | 0.64 ± 0.20 |
| 12. |  |
 |
1 | 1.40 ± 0.62 |
| 13. |  |
 |
1 | 0.97 ± 0.053 |
| 14. |  |
 |
1 | 0.55 ± 0.091 |
| 15. |  |
 |
1 | 2.08 ± 0.59 |
| 16. |  |
 |
1 | 1.31 ± 0.16 |
| 17 |  |
 |
1 | 0.42 ± 0.080 |
| 18. |  |
 |
1 | 0.63 ± 0.22 |
| 19. |  |
 |
1 | 1.50 ± 0.78 |
| 20. |  |
 |
1 | 1.90 ± 0.20 |
| 21. |  |
 |
1 | 0.81 ± 0.12 |
| 22. |  |
 |
1 | 1.66 ± 1.21 |
| 23. |  |
 |
1 | 1.53 ± 1.68 |
| 24. |  |
 |
1 | 5.01 ± 1.33 |
| 25. |  |
 |
1 | 1.40 ± 0.62 |
| 26. |  |
 |
1 | 3.44 ± 0.97 |
| 27. |  |
 |
2 | 2.03 ± 0.61 |
| 28. |  |
 |
3 | 1.74 ± 0.61 |