Fig. 2.
Lesion network localization of disordered volition. (A) Five representative lesions (of 28 total) causing akinetic mutism, demonstrating heterogeneity of lesion location. (B) Percentage of lesion locations functionally connected to each brain voxel. (C) t test comparing functional connectivity of lesions causing akinetic mutism vs. lesions causing hemiparesis (voxel-wise few-corrected P < 0.05). (D) Region of interest in the anterior cingulate centered on our peak site of lesion network overlap from B. (E) Functional connectivity with this region of interest defines a brain network (blue) that encompasses heterogeneous lesion locations disrupting volition (red).