Figure 3.
Association between sarcomere mutations and clinical outcomes. Kaplan-Meier survival analyses were performed in the genotyped hypertrophic cardiomyopathy (HCM) subset. Compared with patients with HCM without sarcomere mutations (SARC−), sarcomere mutation carriers (SARC+) have earlier and a higher incidence of adverse outcomes, particularly those with pathogenic and likely pathogenic variants. A, The risk of developing the overall composite outcome by age 50 years is 29.1% for SARC+ patients vs 24.9% for carriers of a variant of unknown significance (SARC VUS) and 14.2% for SARC− patients. B, Ventricular arrhythmia composite outcome. C, Heart failure composite outcome. D, Atrial fibrillation.