Figure 1.
Changes in SPAP and Organ Weights after MCT Treatment in PAH Rats
(A) SPAP in the MCT group was much higher than in the MCT plus melatonin group, and both of them were much higher than the control group (*p < 0.05 as compared with the control group, #p < 0.05 as compared with the MCT group). (B) Weight of RV in the MCT group was much higher than in the MCT plus melatonin and control groups, and both of them were higher than that of the control group (*p < 0.05 as compared with the control group, #p < 0.05 as compared with the MCT group). (C) The MCT group exhibited a lower weight of LV + IVS compared with the MCT plus melatonin group, and the MCT plus melatonin group showed a lower weight of LV + IVS than the control group (*p < 0.05 as compared with the control group, #p < 0.05 as compared with the MCT group). (D) The MCT group exhibited a higher RV/(LV + IVS) compared with the MCT plus melatonin group, and the MCT plus melatonin group showed a higher RV/(LV + IVS) than the control group (*p < 0.05 as compared with the control group, #p < 0.05 as compared with the MCT group). (E) Ratio of medial thickening in the MCT group was much higher than in the MCT plus melatonin group, and both of them were much higher than the control group (*p < 0.05 as compared with the control group, #p < 0.05 as compared with the MCT group).