Figure 3. PD-L1 positivity and increased TILs is associated with better outcome in lung carcinomas.
(a, b) Kaplan-Meier graphical analysis of 5-year survival in patients with lung carcinomas in the Greek cohort (a) and the Yale University cohort (b) according to PD-L1 protein status. In both cohorts PD-L1-positive patients (black line) showed longer survival compared with negative cases (gray lines, log-rank P=0.0276 for Greek cohort and P=0.0369 for the Yale University cohort). (c, d) 5-Year survival in patients with lung carcinomas in the Greek cohort (c) and the Yale University cohort (d) according to PD-L1 mRNA status. PD-L1 mRNA-positive patients (black line) showed longer survival compared with negative cases (gray lines, log-rank P=0.012 for Greek cohort and P=0.003 for the Yale University cohort). (e, f) 5-Year survival in patients with lung carcinomas in the Greek cohort (e) and the Yale University cohort (f) according to the lymphocytic infiltrate. Cases with high lymphocytic infiltrate (black line, scores 2 and 3) showed longer survival compared with cases with low TILs (gray lines, scores 0 and 1) in both cohorts (log-rank P=0.0158 and 0.009, respectively). The number of cases in each group is indicated within the chart.