. Author manuscript; available in PMC: 2018 Aug 17.

Published in final edited form as: Science. 2018 Jun 22;360(6395):eaap8757. doi: 10.1126/science.aap8757

Table 1. Brain disorder phenotypes used in the Brainstorm project.

Indented phenotypes are part of a larger whole (e.g., the epilepsy study contains the samples from both focal epilepsy and generalized epilepsy). “Anxiety disorders” refers to a meta-analysis of five subtypes (generalized anxiety disorder, panic disorder, social phobia, agoraphobia, and specific phobias). References are listed in table S1 and data availability in table S13 PGC-ADD2, Psychiatric Genomics Consortium (PGC) Attention Deficit Disorder Working Group; PGC-ED, PGC Eating Disorder Working Group; ANGST, Anxiety Neuro Genetics STudy; PGC-AUT, PGC Autism Spectrum Disorder Working Group; PGC-BIP2, PGC Bipolar Disorder Working Group; PGC-MDD2, PGC Major Depressive Disorder Working Group; PGC-OCDTS, PGC Obsessive Compulsive Disorder and Tourette Syndrome Working Group; PGC-PTSD, PGC Posttraumatic Stress Disorder Working Group; PGC-SCZ2, PGC Schizophrenia Working Group; IGAP, International Genomics of Alzheimer’s Project; ILAE, International League Against Epilepsy Consortium on Complex Epilepsies; ISGC, International Stroke Genetics Consortium; METASTROKE, a consortium of the ISGC; IHGC, International; Headache Genetics Consortium; IMSGC, International Multiple Sclerosis Genetics Consortium; IPDGC, International Parkinson’s Disease Genomics Consortium. W indicates same as above.

Psychiatric disorders				Neurological disorders
Disorder	Source	Cases	Controls	Disorder	Source	Cases	Controls
Attention deficit hyperactivity disorder	PGC-ADD2	12,645	84,435	Alzheimer’s disease	IGAP	17,008	37,154
Anorexia nervosa	PGC-ED	3495	10,982	Epilepsy	ILAE	7779	20,439
Anxiety disorders	ANGST	5761	11,765	Focal epilepsy	“	4601^*	17,985^*
Autism spectrum disorder	PGC-AUT	6197	7377	Generalized epilepsy	“	2525^*	16,244^*
Bipolar disorder	PGC-BIP2	20,352	31,358	Intracerebral hemorrhage	ISGC	1545	1481
Major depressive disorder	PGC-MDD2	66,358	153,234	Ischemic stroke	METASTROKE	10,307	19,326
Obsessive-compulsive disorder	PGC-OCDTS	2936	7279	Cardioembolic stroke	“	1859^*	17,708^*
Posttraumatic stress disorder	PGC-PTSD	2424	7113	Early onset stroke	“	3274^*	11,012*
Schizophrenia	PGC-SCZ2	33,640	43,456	Large-vessel disease	“	1817^*	17,708^*
Tourette syndrome	PGC-OCDTS	4220	8994	Small-vessel disease	“	1349^*	17,708^*
				Migraine	IHGC	59,673	316,078
				Migraine with aura	“	6332^*	142,817^*
				Migraine without aura	“	8348^*	136,758^*
				Multiple sclerosis	IMSGC	5545	12,153
				Parkinson’s disease	IPDGC	5333	12,019
Total psychiatric		158,028	365,993	Total neurologic		107,190	418,650

Sample count for a phenotype that is part of a larger group.