Table 8.
Change from baseline of liver and spleen volumes at Week 52
| patient | liver | spleen | ||||||
|---|---|---|---|---|---|---|---|---|
| baseline | 52 weeks | baseline | 52 weeks | |||||
| mL | %BW | mL | %BW | mL | %BW | mL | %BW | |
| 202 | 445.7 | 2.27 | 404.4 | 1.96 | 76.3 | 0.39 | 87.8 | 0.43 |
| 203 | 546.1 | 2.86 | 518.7 | 2.44 | 108.9 | 0.57 | 107.3 | 0.50 |
| 204 | 930.0 | 2.51 | 800.9 | 1.75 | 149.1 | 0.40 | 107.6 | 0.24 |
| 205 | 691.1 | 2.80 | 548.8 | 1.78 | 174.0 | 0.70 | 107.1 | 0.35 |
| 206 | 570.2 | 4.92 | 486.2 | 3.33 | 87.7 | 0.76 | 75.5 | 0.52 |
| 207 | 529.3 | 2.82 | 483.7 | 2.27 | 209.7 | 1.12 | 181.1 | 0.85 |
| 211 | 528.1 | 4.63 | 434.2a | 3.37 | 88.0 | 0.77 | 58.1a | 0.45 |
| 213 | 1273.5 | 3.31 | 1198.4 | 2.65 | 210.7 | 0.55 | 247.1 | 0.55 |
| 214 | 601.5 | 4.63 | 530.6 | 3.38 | 139.0 | 1.07 | 118.4 | 0.75 |
| 215 | 702.6 | 1.77 | 765.7 | 1.50 | 202.9 | 0.51 | 202.5 | 0.40 |
| 216 | 578.6 | 2.19 | 642.5 | 2.09 | 168.2 | 0.64 | 156.4 | 0.51 |
| mean | 672.4 | 3.15b | 619.5 | 2.41b | 146.8 | 0.68c | 131.7 | 0.50c |
| SEM | 71.8 | 0.33 | 69.8 | 0.21 | 15.4 | 0.07 | 17.6 | 0.05 |
a52-week MRI could not be performed; difference computed from 26-week volume
bLiver %BW at 52 weeks is significantly reduced compared to %BW at baseline (P<0.0005)
cSpleen %BW at 52 weeks is significantly reduced compared to %BW at baseline (P<0.005)