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. 2018 Jun 20;19(6):1816. doi: 10.3390/ijms19061816

Figure 1.

Figure 1

① Nesvacumab activates Tie-2 signaling and decreases vascular permeability by inhibiting Ang-2, an antagonist of Tie2. ② AKB-9778 activates Tie-2 signaling by inhibiting ③ VE-PTP, a negative regulator of Tie-2.