Figure 3.
Upstream open reading frames (uORFs) can have different functions in preferential translation in the integrated stress response (ISR). The uORFs and their function are highlighted for the indicated gene transcripts. The 5′-leader of the messenger RNAs (mRNAs) is indicated as a solid line. The coding sequences (CDSs) are indicated by the bar on the far right of each transcript, with uORFs indicated by the light gray bars. Scanning and elongating ribosomes are indicated by the ovals, with small and large ribosomal subunits. Arrows indicate ribosome bypass, reinitiation or termination, and release.